COLONEL: Samuel Bayless
- DATES: November 1814 – May 1815
- MEN MOSTLY FROM: Washington, Jefferson, Carter, Claiborne, Cocke, Grainger, Greene, and Sullivan Counties.
CAPTAINS: Joseph Bacon, John Brock, James Churchman, Joseph Goodson, Joseph Hale, Solomon Hendricks, Branch Jones, James Landen, Joseph Rich, and Jonathan Waddle.
This regiment, along with Colonel William Johnson’s Third Regiment and Colonel Edwin Booth’s Fifth Regiment, defended the lower section of the Mississippi Territory, particularly the vicinity of Mobile. They protected the region from possible Indian incursions and any British invasion. These regiments were under the command of Major General William Carroll. They manned the various forts that were located throughout the territory: Fort Claiborne, Fort Decatur, and Fort Montgomery, for example. Sickness was rampant in this regiment and the desertion rate was high. The regiment mustered in at Knoxville and was dismissed at Mobile.